Description

3,3',5'-Tribromophlorhizin is a brominated derivative of the natural product phlorizin, a compound of significant interest in biochemical research. Its value lies in its utility as a specialized synthetic intermediate and a potent, selective probe for investigating biological pathways, particularly those involving glucose transport and enzyme inhibition. This high-purity compound is primarily needed by research institutions and pharmaceutical development laboratories focused on metabolic disorders, diabetes research, and the discovery of novel therapeutic agents.

Application

• Biochemical Research Probe: Used as a selective inhibitor to study sodium-glucose linked transporters (SGLTs) and related cellular glucose uptake mechanisms.
• Pharmaceutical Intermediate: Serves as a key synthetic building block in the development of potential drug candidates targeting metabolic diseases.
• Enzyme Inhibition Studies: Employed in vitro to investigate the activity and kinetics of specific enzymes, such as glycosidases.
• Reference Standard: Utilized as a high-purity analytical standard in HPLC and LC-MS methods for quality control and method validation in research settings.
• Medicinal Chemistry: Provides a brominated scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.

Basic Information

Item	Details
Product Name	3,3',5'-Tribromophlorhizin
CAS No.	86158-09-0
Molecular Formula	C21H21Br3O10
Molecular Weight	665.10 g/mol
Synonyms	3,3',5'-Tribromophlorizin; 2-(4-((2S,3R,4S,5S,6R)-3,5-Dibromo-4-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-2,6-dibromophenyl)-5,7-dihydroxy-4H-chromen-4-one; Tribromophlorhizin; Phlorhizin Tribromo Derivative
EINECS	Contact for details

Quality Control

Our 3,3',5'-Tribromophlorhizin is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant standards for research chemicals, and specifications can be provided to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.