Description

Fmoc-Glu(Otbu)-Opfp CAS NO 86061-04-3 is a protected amino acid derivative, specifically an Fmoc-glutamic acid γ-tert-butyl ester activated with pentafluorophenyl (OPfp). This compound is a critical building block in solid-phase peptide synthesis (SPPS), offering high coupling efficiency and minimal racemization. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected, side-chain protected glutamic acid derivative for the efficient, sequential assembly of peptide chains.
• Peptide Library Construction: For the combinatorial synthesis of diverse peptide libraries used in drug discovery and high-throughput screening.
• Synthesis of Glutamate-Containing Peptides: Specifically for incorporating glutamic acid residues with a protected carboxylic acid side chain into target sequences.
• Bioconjugation and Labeling: The reactive OPfp ester group can be utilized for selective conjugation to amines in other biomolecules.
• Research & Development: Fundamental research in peptide chemistry, structure-activity relationship (SAR) studies, and the development of therapeutic peptides.
• Process Development: Scaling up the synthesis of specific peptide-based active pharmaceutical ingredients (APIs) or intermediates.

Basic Information

Product Name	Fmoc-Glu(Otbu)-Opfp
CAS No.	86061-04-3
Molecular Formula	C₃₀H₂₈F₅NO₆
Molecular Weight	581.55 g/mol
Synonyms	Fmoc-Glu(OtBu)-OPfp; Fmoc-L-glutamic acid 5-tert-butyl ester pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid 1-tert-butyl 5-pentafluorophenyl ester; Fmoc-Glu(OtBu)-OPfp ester; Fmoc-Glu(γ-OtBu)-OPfp; Nα-Fmoc-L-glutamic acid γ-tert-butyl ester α-pentafluorophenyl ester; Fmoc-L-Glu(OtBu)-OPfp; Pentafluorophenyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutam-5-yl tert-butyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(Otbu)-Opfp is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive peptide synthesis applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.