Description

Fmoc-Cys(Acm)-Opfp is a specialized, high-purity amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise, side-chain protected cysteine incorporation into peptide chains. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic laboratories engaged in the development of therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Key building block for the controlled introduction of cysteine residues with orthogonal Acm (acetamidomethyl) side-chain protection.
• Therapeutic Peptide Development: Enables the synthesis of peptides targeting metabolic disorders, oncology, and infectious diseases where disulfide bridge formation is crucial for bioactivity.
• Bioconjugation and Labeling: Serves as a precursor for site-specific modification of peptides and proteins via the deprotected thiol group of cysteine.
• Chemical Biology Research: Used in the study of protein-protein interactions, enzyme mechanisms, and the creation of peptide-based inhibitors or probes.
• Production of Peptide APIs: Employed in the scalable, GMP-compliant manufacturing of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Combinatorial Library Synthesis: Facilitates the generation of diverse peptide libraries for high-throughput screening in drug discovery campaigns.

Basic Information

Product Name	Fmoc-Cys(Acm)-Opfp
CAS No.	86060-96-0
Molecular Formula	C26H19F5N2O5S
Molecular Weight	566.50 g/mol
Synonyms	Fmoc-Cys(Acm)-OPfp; Fmoc-S-acetamidomethyl-L-cysteine pentafluorophenyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(acetamidomethyl)-L-cysteine 2,3,4,5,6-pentafluorophenyl ester; Fmoc-Cysteine(Acm)-OPfp ester; Fmoc-L-Cys(Acm)-OPfp; Nα-Fmoc-S-acetamidomethyl-L-cysteine pentafluorophenyl ester; Fmoc-Cys(Acm)-OPfp Pentafluorophenyl Ester
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(Acm)-Opfp is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines
Water Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.