Description

Fmoc-Phe-Opfp is a highly reactive, protected amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound is specifically designed for the efficient and selective incorporation of phenylalanine into peptide chains under mild conditions. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and complex biomolecules. The product is supplied as a high-purity reagent to ensure optimal coupling yields and minimal side reactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester (pentafluorophenyl ester), it is a key reagent for the rapid and racemization-free coupling of Fmoc-protected phenylalanine.
• Pharmaceutical Intermediate: Used in the research and GMP-scale production of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation: Facilitates the site-specific labeling of peptides and proteins with various probes, tags, or payloads for diagnostic and research applications.
• Combinatorial Chemistry: A valuable building block in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Academic & Industrial Research: Employed in biochemistry and molecular biology labs for custom peptide synthesis and structure-activity relationship (SAR) studies.
• Production of Protected Peptide Fragments: Used in solution-phase synthesis for the preparation of larger, complex peptide segments.

Basic Information

Product Name	Fmoc-Phe-Opfp
CAS No.	86060-92-6
Molecular Formula	C30H20F5NO5
Molecular Weight	569.48 g/mol
Synonyms	Fmoc-L-Phenylalanine pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine pentafluorophenyl ester; Fmoc-Phenylalanine-OPfp; Fmoc-Phe-OPfp; Fmoc-Phe-O-Pfp; N-α-Fmoc-L-phenylalanine pentafluorophenyl ester; (9H-Fluoren-9-ylmethoxy)carbonyl-L-phenylalanine 2,3,4,5,6-pentafluorophenyl ester; Fmoc-Phenylalanine pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Phe-Opfp is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can support requirements for research, cGMP, or other regulatory frameworks upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.