Description

(9S)-10,11-Dihydro-9-Hydroxy-6'-Methoxycinchonanium Hydrogen Sulphate is a high-purity, chiral cinchona alkaloid derivative. This compound is valued for its role as a versatile and highly selective organocatalyst and chiral selector in asymmetric synthesis. It is primarily sought by research and development laboratories, as well as production facilities, in the pharmaceutical and fine chemical industries for the synthesis of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Synthesis: Employed as a chiral phase-transfer catalyst (PTC) for enantioselective alkylation, Michael addition, and other carbon-carbon bond-forming reactions.
• Chiral Resolution: Used as a chiral selector or resolving agent in the separation of racemic mixtures via techniques like diastereomeric salt crystallization.
• Pharmaceutical Intermediates: A key building block in the synthesis of complex, biologically active molecules requiring specific stereochemistry.
• Catalyst Ligand Precursor: Serves as a precursor for developing novel chiral ligands used in metal-catalyzed asymmetric transformations.
• Analytical Chemistry: Utilized in the preparation of chiral stationary phases for high-performance liquid chromatography (HPLC) to separate enantiomers.
• Academic & Industrial R&D: A critical reagent for methodological development in organic chemistry and process optimization.

Basic Information

Item	Details
Product Name	(9S)-10,11-Dihydro-9-Hydroxy-6'-Methoxycinchonanium Hydrogen Sulphate
CAS No.	85909-60-0
Molecular Formula	C₂₀H₂₆N₂O₆S
Molecular Weight	422.50 g/mol
Synonyms	(9S)-10,11-Dihydro-9-hydroxy-6'-methoxycinchonan-9-ium hydrogen sulfate; (9S)-Dihydro-9-hydroxy-6'-methoxycinchonanium bisulfate; Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)-, sulfate (1:1); 6'-Methoxy-9-epi-cinchonidine sulfate; Dihydro-9-hydroxy-6'-methoxycinchonanium sulfate; Chiral Cinchona Alkaloid Sulfate Salt; PTC Catalyst Derivative
EINECS	Contact for details

Quality Control

Every batch of our (9S)-10,11-Dihydro-9-Hydroxy-6'-Methoxycinchonanium Hydrogen Sulphate is produced and tested under a strict quality management system. We ensure high chiral purity and chemical integrity through advanced analytical techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity, assay, and impurity profile is provided with each shipment to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.