Description

2-Chloro-5-Methoxy-4-(2-Pyridylamino)Aniline is a specialty aromatic amine derivative featuring a chloro-methoxy-substituted aniline core coupled with a 2-pyridylamino moiety — a structural motif associated with high selectivity in heterocyclic pharmaceutical intermediates. This compound serves as a critical building block for the synthesis of advanced agrochemical actives and kinase-targeted therapeutic agents, where precise regiochemical control and nitrogen basicity are essential. It is primarily utilized by R&D laboratories and fine chemical manufacturers engaged in custom synthesis of bioactive molecules for oncology, crop protection, and veterinary medicine development.

Application

• Synthesis of selective herbicides and fungicides targeting pyridylamine-sensitive plant enzyme pathways
• Key intermediate in the manufacture of tyrosine kinase inhibitors (TKIs) for targeted cancer therapies
• Building block for novel veterinary antiparasitic agents with improved metabolic stability
• Chemical probe development for structure–activity relationship (SAR) studies in medicinal chemistry
• Custom synthesis of photoactive dyes and functionalized ligands for metal–organic frameworks (MOFs)
• Research-grade reagent for asymmetric amination and cross-coupling methodologies (e.g., Buchwald–Hartwig)

Basic Information

Product Name	2-Chloro-5-Methoxy-4-(2-Pyridylamino)Aniline
CAS No.	85896-07-7
Molecular Formula	C12H12ClN3O
Molecular Weight	249.70 g/mol
Synonyms	2-Chloro-5-methoxy-N-(pyridin-2-yl)benzene-1,4-diamine; 2-Chloro-5-methoxy-4-[(2-pyridyl)amino]aniline; 4-Amino-2-chloro-5-methoxy-N-(2-pyridyl)aniline; NSC 654207; PYR-ANL-CL-OMe; 2-(4-Amino-2-chloro-5-methoxyphenylamino)pyridine; CLMPOA; 2-Chloro-5-methoxy-4-(pyridin-2-ylamino)aniline
EINECS	Not listed (not pre-registered under REACH as of 2024)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are verified for identity (IR, HPLC retention time), purity (≥98.5% by HPLC), and absence of heavy metals (≤10 ppm). Testing follows ACS Reagent Grade protocols and is conducted in ISO/IEC 17025-accredited laboratories. Full traceability and batch-specific COAs support regulatory submissions including FDA IND and EMA CTA filings.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity. Avoid contact with strong oxidizing agents and strong alkalis.

Specification

Item	Specification
Appearance	Pale yellow to brown crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	≤1.0% total impurities
Residue on Ignition	≤0.1%
Water (Karl Fischer)	≤0.5%
Heavy Metals	≤10 ppm
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.