Description

Pyrimethamine Pamoate is a pharmaceutical salt form of the antiparasitic agent pyrimethamine, designed to enhance stability and bioavailability. This compound is critical for the development of long-acting therapeutic formulations targeting specific parasitic infections. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development of antiprotozoal and antimalarial medications.

Application

• Pharmaceutical Intermediates: Serves as a key active pharmaceutical ingredient (API) or intermediate in the synthesis of finished dosage forms.
• Antimalarial Drug Development: Used in research and production of medications for the treatment and prevention of malaria, often in combination therapies.
• Antiprotozoal Therapeutics: Employed in formulations targeting infections caused by Toxoplasma gondii and other protozoan parasites.
• Veterinary Medicine: Applied in the development of treatments for parasitic infections in animals.
• Long-Acting Injectable Formulations: The pamoate salt is utilized to create depot injections that provide sustained release of the active drug over an extended period.
• Biochemical Research: Acts as a dihydrofolate reductase (DHFR) inhibitor in enzymatic studies and mechanism of action research.

Basic Information

Product Name	Pyrimethamine Pamoate
CAS No.	85819-86-9
Molecular Formula	C12H13ClN4 • C23H16O6
Molecular Weight	696.13 g/mol
Synonyms	Pyrimethamine Embonate; Daraprim Pamoate; 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine compound with 4,4'-Methylenebis[3-hydroxy-2-naphthoic acid]; 2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine pamoate; Pyrimethamine 4,4'-Methylenebis(3-hydroxy-2-naphthoate); WR-4873; CL-13900; RP 4753
EINECS	Contact for details

Quality Control

Our Pyrimethamine Pamoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting specifications suitable for pharmaceutical research and development. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.