Description

Ambamustine CAS NO 85754-59-2 is a specialized pharmaceutical intermediate and research chemical of significant interest in advanced therapeutic development. Its primary value lies in its role as a key building block for synthesizing novel compounds, particularly in oncology research. This product is essential for pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on developing next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially in the oncology and cytostatic therapeutic areas.
• Research & Development: Used as a reference standard and starting material in medicinal chemistry for structure-activity relationship (SAR) studies and new molecular entity (NME) discovery.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the controlled synthesis of specific alkylating agent derivatives under Good Manufacturing Practice (GMP) conditions where applicable.
• Biochemical Research: Utilized in vitro studies to investigate mechanisms of action related to DNA alkylation and cellular apoptosis pathways.
• Fine Chemical Production: Acts as a high-value intermediate for contract manufacturing organizations (CMOs) producing custom chemicals for clinical trial materials.

Basic Information

Product Name	Ambamustine
CAS No.	85754-59-2
Molecular Formula	C7H16Cl2N4O3
Molecular Weight	275.13 g/mol
Synonyms	Ambamustine; 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) derivative; Lomustine analog; NSC-D-254781; 1-(2-Chloroethyl)-3-[(2-chloroethyl)amino]carbonyl]-1-nitrosourea; Nitrosourea derivative; Chloroethylnitrosourea; Anti-neoplastic alkylating agent intermediate
EINECS	Contact for details

Quality Control

Our Ambamustine is produced and handled under strict quality management systems to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting specifications for purity, related substances, and residual solvents. We support compliance with ICH Q7 guidelines and can provide material suitable for research use under GMP-like controls upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider inert atmosphere packaging to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.