Description

Methyl 8-Ethyl-5,6,7,8-tetrahydro-2-(methylthio)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the pyridopyrimidine class of heterocyclic compounds. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), valued for its precise molecular architecture that enables targeted drug development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the discovery and production of novel therapeutic agents, particularly in oncology and antiviral research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Oncology Research: Serves as a core scaffold for the development of novel kinase inhibitors and other targeted cancer therapies.
• Antiviral Drug Development: Used in research programs aimed at creating new antiviral compounds.
• Chemical Biology & Medicinal Chemistry: Employed as a versatile building block for structure-activity relationship (SAR) studies and library synthesis.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production under cGMP conditions.
• Contract Research & Manufacturing (CRO/CMO): Provided to service organizations supporting global pharmaceutical R&D pipelines.

Basic Information

Product Name	Methyl 8-Ethyl-5,6,7,8-Tetrahydro-2-(Methylthio)-5-Oxopyrido[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	85702-59-6
Molecular Formula	C₁₃H₁₇N₃O₃S
Molecular Weight	295.36 g/mol
Synonyms	Methyl 8-ethyl-2-(methylthio)-5-oxo-5,6,7,8-tetrahydro-2H-pyrido[2,3-d]pyrimidine-6-carboxylate; 6-Carbomethoxy-8-ethyl-2-methylmercapto-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine; 8-Ethyl-2-methylthio-5-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-6-carboxylic acid methyl ester; 85702-59-6; Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 8-ethyl-5,6,7,8-tetrahydro-2-(methylthio)-5-oxo-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 8-Ethyl-5,6,7,8-tetrahydro-2-(methylthio)-5-oxopyrido[2,3-d]pyrimidine-6-carboxylate adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. We operate in compliance with relevant ISO standards and can support development programs requiring ICH stability guidelines or cGMP documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.