Description

Methyl 1-(Chlorocarbonyl)-L-Prolinate is a high-purity chiral building block and activated ester derivative of L-proline. This compound is a critical intermediate for the synthesis of complex pharmaceutical molecules, particularly in the development of protease inhibitors and other active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in peptide-mimetic drug discovery and GMP production.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptidomimetics and protease inhibitor drugs.
• Peptide Chemistry: Used as an activated ester for peptide coupling reactions, facilitating the incorporation of proline derivatives.
• API Development: Serves as a crucial building block in the research and scale-up production of new chemical entities (NCEs).
• Bioconjugation: Potential reagent for modifying biomolecules due to its reactive carbonyl chloride group.
• Asymmetric Synthesis: Provides a chiral scaffold for constructing complex molecules with defined stereochemistry in medicinal chemistry.
• Custom Synthesis: Starting material for contract research organizations (CROs) and CDMOs producing specialized fine chemicals.

Basic Information

Product Name	Methyl 1-(Chlorocarbonyl)-L-Prolinate
CAS No.	85665-59-4
Molecular Formula	C7H10ClNO3
Molecular Weight	191.61 g/mol
Synonyms	L-Proline, 1-(chlorocarbonyl)-, methyl ester; Methyl L-prolinate chloroformate; 1-(Methoxycarbonyl)-L-proline acid chloride; Methyl 1-chloroformyl-L-prolinate; (S)-1-(Chlorocarbonyl)pyrrolidine-2-carboxylic acid methyl ester; Methyl (S)-1-(chlorocarbonyl)pyrrolidine-2-carboxylate; Proline derivative 85665-59-4; Activated L-Proline methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 1-(Chlorocarbonyl)-L-Prolinate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.