Description

8-(N,N-Dimethyl)Mitozolomide is a dimethylated derivative of the potent alkylating agent mitozolomide. This compound is of significant interest in pharmaceutical research and development, particularly for the synthesis of novel chemotherapeutic agents and as a key intermediate in advanced drug discovery programs. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in oncology research and the development of next-generation anticancer therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced chemotherapeutic agents and experimental oncology drugs.
• Biomedical Research: Used as a reference standard and active compound in in vitro and in vivo studies to investigate mechanisms of DNA alkylation and cytotoxicity.
• Drug Discovery: Employed in medicinal chemistry programs for the design and optimization of new mitozolomide analogs with improved efficacy or reduced side-effect profiles.
• Academic Research: Utilized in university and institutional labs for fundamental studies on the biochemistry of DNA damage and repair pathways.
• Preclinical Development: Acts as a key material in the production of batches for toxicology, pharmacokinetics, and stability testing during early-stage drug development.

Basic Information

Product Name	8-(N,N-Dimethyl)Mitozolomide
CAS No.	85623-00-3
Molecular Formula	C9H13N5O3
Molecular Weight	239.23 g/mol
Synonyms	8-(Dimethylamino)mitozolomide; 8-Dimethylaminomitozolomide; Mitozolomide 8-(N,N-dimethyl) derivative; 3,4-Dihydro-3-methyl-4-oxo-8-(dimethylamino)imidazo[5,1-d][1,2,3,5]tetrazine-4-carboxamide; CCRG 81010 dimethyl derivative; NSC-D 710551 (related); Imidazotetrazine derivative
EINECS	Contact for details

Quality Control

Our 8-(N,N-Dimethyl)Mitozolomide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality system supports cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere at lower temperatures (e.g., -20°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.