Description

8-(n-Methyl)Mitozolomide is a methylated derivative of the potent alkylating agent mitozolomide, representing a key intermediate and research compound in oncology drug development. This compound is of significant interest for its potential to modulate DNA alkylation properties and for use in structure-activity relationship (SAR) studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and specialty chemical manufacturers focused on developing novel chemotherapeutic agents and exploring mechanisms of action for DNA-targeting drugs.

Application

• Pharmaceutical Research & Development: A critical intermediate in the synthesis and study of novel antineoplastic agents targeting DNA alkylation.
• Oncology Drug Discovery: Used in structure-activity relationship (SAR) studies to develop new analogs of mitozolomide with improved efficacy or reduced toxicity profiles.
• Biochemical Research: Employed as a tool compound to investigate the mechanisms of DNA damage and repair pathways in cancer cell lines.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Studies: Utilized in *in vitro* and *in vivo* models to evaluate pharmacokinetics, metabolism, and therapeutic potential.

Basic Information

Product Name	8-(n-Methyl)Mitozolomide
CAS No.	85622-96-4
Molecular Formula	C10H13N5O3
Molecular Weight	251.24 g/mol
Synonyms	8-Methylmitozolomide; 8-Methyl-Mitozolomide; 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; Imidazotetrazine derivative; CCRG 81010 methyl derivative; Methylated Mitozolomide analog; Antitumor agent intermediate
EINECS	Contact for details

Quality Control

Every batch of 8-(n-Methyl)Mitozolomide is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for research applications. Our products undergo rigorous quality testing, and a detailed Certificate of Analysis (COA) documenting purity (typically by HPLC), identity confirmation (IR, NMR), and impurity profiles is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is light-sensitive (store away from light). For long-term storage, consider storing under inert atmosphere at lower temperatures (e.g., -20°C) to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.