Description

Temozolomide CAS NO 85622-93-1 is an alkylating agent belonging to the imidazotetrazine class of compounds. It is a critical active pharmaceutical ingredient (API) valued for its ability to cross the blood-brain barrier and function as a prodrug, converting to its active metabolite under physiological conditions. This product is essential for pharmaceutical manufacturers and research institutions developing treatments for aggressive brain tumors, such as glioblastoma multiforme and astrocytoma, as well as for clinical research into other oncological applications.

Application

• Primary Pharmaceutical Ingredient: Manufacture of oral chemotherapy capsules for the treatment of newly diagnosed and refractory glioblastoma multiforme.
• Oncology Research & Development: Key intermediate in preclinical and clinical studies exploring novel cancer therapies and combination treatment regimens.
• Generic Drug Formulation: Sourcing for companies producing bioequivalent versions of established temozolomide-based medications.
• Clinical Trial Supply: Provision of high-purity API for Phase I-IV clinical trials investigating expanded indications.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation.
• Investigational Formulations: Research into alternative delivery systems, such as injectable or implantable formulations for targeted therapy.

Basic Information

Product Name	Temozolomide
CAS No.	85622-93-1
Molecular Formula	C6H6N6O2
Molecular Weight	194.15 g/mol
Synonyms	Temodal; Temodar; Methazolastone; 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; CCRG 81045; M & B 39831; NSC 362856; TMZ
EINECS	Contact for details

Quality Control

Our Temozolomide is manufactured under strict quality management systems. Each batch is tested to meet stringent specifications for identity, purity, and impurity profiles, aligning with major pharmacopeial standards (e.g., USP, EP). A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, related substances, residual solvents, and other critical parameters to ensure reliability and consistency for your manufacturing and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15°C and 25°C (59°F and 77°F), in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.