Description

(4-Nitrophenyl) (2R)-2-[(2-Methylpropan-2-Yl)Oxycarbonylamino]Propanoate is a specialized chiral building block and activated ester used in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates for the development of pharmaceuticals and fine chemicals. It is primarily utilized by the pharmaceutical, agrochemical, and biotechnology industries for peptide coupling, prodrug synthesis, and the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in peptide-based drug development.
• Prodrug Synthesis: Used as an activated ester for constructing prodrugs, where the 4-nitrophenoxy group acts as a good leaving group for enzymatic or chemical activation.
• Peptide Coupling Reagent: Serves as an efficient coupling agent in solid-phase and solution-phase peptide synthesis to form amide bonds.
• Bioconjugation: Employed in the modification of biomolecules, such as proteins and antibodies, for creating targeted drug delivery systems or diagnostic agents.
• Agrochemical Research: Used in the research and development of novel chiral herbicides, fungicides, and plant growth regulators.
• Material Science: A precursor for synthesizing specialized polymers and functional materials with specific chiral properties.

Basic Information

Product Name	(4-Nitrophenyl) (2R)-2-[(2-Methylpropan-2-Yl)Oxycarbonylamino]Propanoate
CAS No.	85546-27-6
Molecular Formula	C15H20N2O6
Molecular Weight	324.33 g/mol
Synonyms	N-Boc-D-Alanine 4-Nitrophenyl Ester; Boc-D-Ala-ONp; (R)-2-((tert-Butoxycarbonyl)amino)propanoic acid 4-nitrophenyl ester; tert-Butyl ((R)-1-((4-nitrophenoxy)oxy)-1-oxopropan-2-yl)carbamate; Boc-D-Alanine p-nitrophenyl ester; D-Boc-Alanine-ONp; Boc-D-Ala-ONp ester; N-(tert-Butoxycarbonyl)-D-alanine 4-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our production of (4-Nitrophenyl) (2R)-2-[(2-Methylpropan-2-Yl)Oxycarbonylamino]Propanoate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.