Description

Diisopropyl L-Aspartate Hydrochloride is a protected amino acid derivative, specifically the diisopropyl ester hydrochloride salt of L-aspartic acid. This compound is a crucial chiral building block in organic synthesis, valued for its role in introducing the L-aspartate moiety while providing enhanced solubility and handling properties. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the synthesis of peptides, active pharmaceutical ingredients (APIs), and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs and complex APIs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate L-aspartic acid with ester protection.
• Bioconjugation & Linker Chemistry: Serves as a precursor for creating aspartic acid-containing linkers in antibody-drug conjugates (ADCs) and prodrugs.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in asymmetric catalytic reactions to construct stereogenic centers.
• Biochemical Research: Used in academic and industrial R&D for studying enzyme inhibitors, receptor ligands, and metabolic pathways.
• Fine Chemical Production: A building block for manufacturing specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	Diisopropyl L-Aspartate Hydrochloride
CAS No.	85391-04-4
Molecular Formula	C10H20ClNO4
Molecular Weight	253.72 g/mol
Synonyms	L-Aspartic acid diisopropyl ester hydrochloride; H-Asp(OiPr)2-OH · HCl; Diisopropyl (2S)-2-aminobutanedioate hydrochloride; (S)-Diisopropyl 2-aminosuccinate hydrochloride; Diisopropyl L-aspartate HCl; Aspartic acid diisopropyl ester hydrochloride (L-form); 85391-04-4; L-Aspartic acid diisopropyl ester HCl salt
EINECS	Contact for details

Quality Control

Our Diisopropyl L-Aspartate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.