Description

3-Pyridinecarbonyl Chloride, 5-Chloro- (9Ci) is a versatile and reactive heterocyclic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the 5-chloronicotinoyl moiety, a key structural feature in the development of active pharmaceutical ingredients and agrochemicals. This high-purity intermediate is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, insecticides, and fungicides where the chloronicotinate structure enhances bioactivity and selectivity.
• Ligand and Catalyst Development: Employed in organic and organometallic chemistry to create novel pyridine-based ligands for catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers, dyes, and photoactive materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client R&D pipelines.

Basic Information

Product Name	3-Pyridinecarbonyl Chloride, 5-Chloro- (9Ci)
CAS No.	85320-79-2
Molecular Formula	C6H3Cl2NO
Molecular Weight	176.00 g/mol
Synonyms	5-Chloronicotinoyl chloride; 5-Chloropyridine-3-carbonyl chloride; 3-Carbonyl chloride-5-chloropyridine; 5-Chloro-3-pyridinecarboxylic acid chloride; 5-Chloronicotinic acid chloride; 5-Chloro-3-pyridinylcarbonyl chloride; 5-Chloro-3-pyridinecarbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Pyridinecarbonyl Chloride, 5-Chloro- (9Ci) is manufactured under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy to ensure identity, purity, and consistency meet the exacting standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and maintain product integrity. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.