Description

1-Boc-3-Hydroxypiperidine is a versatile and high-purity protected piperidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in providing a reactive hydroxyl group shielded by a Boc (tert-butoxycarbonyl) protecting group, enabling precise and selective chemical transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of various drug candidates, including central nervous system (CNS) agents and receptor modulators.
• Peptidomimetic Chemistry: Used to incorporate constrained piperidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with specific stereochemical requirements.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and R&D: A fundamental starting material for contract research organizations (CROs) and academic laboratories engaged in novel heterocyclic chemistry.

Basic Information

Product Name	1-Boc-3-Hydroxypiperidine
CAS No.	85275-45-2
Molecular Formula	C10H19NO3
Molecular Weight	201.26 g/mol
Synonyms	3-Hydroxypiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-hydroxypiperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-hydroxypiperidine; 3-Hydroxy-1-N-Boc-piperidine; N-Boc-3-piperidinol; 1-Boc-3-piperidinol; N-Boc-3-hydroxypiperidine; 3-Piperidinol, 1-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Hydroxypiperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.