Description

Tris(tert-Butyldimethylsilyl) Phosphite is a specialized organosilicon phosphite derivative, valued for its role as a versatile protecting group reagent and a precursor in advanced organic synthesis. Its primary commercial significance lies in its ability to act as a highly effective silylating agent for phosphorus-containing compounds, facilitating complex molecular transformations. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors, particularly in the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of complex drug molecules, particularly for protecting phosphate groups during multi-step synthesis.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where phosphorus-based intermediates are required.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized phosphite ligands used in asymmetric catalysis and transition metal complexes.
• Polymer Chemistry: Employed as a modifying agent or stabilizer in the synthesis of high-performance polymers and resins.
• Organometallic Chemistry: Crucial for the preparation of silyl-protected phosphorous compounds used in research and development.
• Fine Chemical Production: Utilized in custom synthesis and the manufacture of high-value, low-volume specialty chemicals.

Basic Information

Product Name	Tris(tert-Butyldimethylsilyl) Phosphite
CAS No.	85197-27-9
Molecular Formula	C18H45O3PSi3
Molecular Weight	424.78 g/mol
Synonyms	Phosphorous Acid Tris(tert-butyldimethylsilyl) Ester; Tris-O-(tert-butyldimethylsilyl) Phosphite; TBDMS Phosphite; Tris(TBDMS) Phosphite; tert-Butyldimethylsilyl Phosphite (Tris); HP(O)[OSi(CH3)2C(CH3)3]3; Phosphorous Acid Tris(1,1-Dimethylethyl)dimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our Tris(tert-Butyldimethylsilyl) Phosphite is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.