Description

Dimethyl (Trimethylsilyloxycarbonylmethyl)Phosphonate is a specialized organophosphorus reagent featuring a silyl-protected phosphonate ester group. This compound is valued for its role as a key synthetic intermediate in the preparation of α-hydroxy phosphonates and other complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing carbon-phosphorus bonds under mild conditions.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly those with phosphonate or bisphosphonate moieties for therapeutic applications.
• Agrochemical Synthesis: Used in the research and development of new herbicides, plant growth regulators, and other crop protection agents.
• Ligand and Catalyst Preparation: Serves as a precursor for phosphonate-based ligands used in asymmetric catalysis and metal complexation.
• Material Science Research: Employed in the development of flame retardants, specialty polymers, and surface-modifying agents.
• Academic & Industrial R&D: A versatile reagent for method development in organic synthesis, including Horner-Wadsworth-Emmons (HWE) olefination and other carbon-carbon bond-forming reactions.

Basic Information

Product Name	Dimethyl (Trimethylsilyloxycarbonylmethyl)Phosphonate
CAS No.	85169-29-5
Molecular Formula	C8H19O5PSi
Molecular Weight	254.29 g/mol
Synonyms	Dimethyl (Trimethylsilyloxycarbonylmethyl)Phosphonate; (Trimethylsilyloxycarbonylmethyl)phosphonic Acid Dimethyl Ester; Dimethyl [(Trimethylsilyloxy)carbonyl]methylphosphonate; Phosphonic acid, P-[(trimethylsilyloxy)carbonyl]-, dimethyl ester; TMS-POMe
EINECS	Contact for details

Quality Control

Our Dimethyl (Trimethylsilyloxycarbonylmethyl)Phosphonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.