Description

Ethyl 10-[(Hydroxyamino)Carbonyl]-1,4-Dioxa-7-Azaspiro[4.5]Decane-7-Carboxylate is a sophisticated heterocyclic building block featuring a spirocyclic core with both ester and hydroxamic acid derivative functionalities. This compound matters as a key synthetic intermediate for the development of novel pharmacologically active molecules, particularly in medicinal chemistry research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential drug candidates, especially those targeting enzymes like histone deacetylases (HDACs) due to its hydroxamic acid moiety.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probes: Employed in the development of molecular probes to study biological pathways and protein function.
• Organic Synthesis Building Block: Utilized for constructing complex spirocyclic and heterocyclic compounds in advanced synthetic chemistry.
• Agrochemical Research: Potential intermediate in the development of new active ingredients for crop protection.

Basic Information

Product Name	Ethyl 10-[(Hydroxyamino)Carbonyl]-1,4-Dioxa-7-Azaspiro[4.5]Decane-7-Carboxylate
CAS No.	85118-31-6
Molecular Formula	C12H20N2O6
Molecular Weight	288.30 g/mol
Synonyms	Ethyl 10-(hydroxycarbamoyl)-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate; 7-Carbethoxy-1,4-dioxa-7-azaspiro[4.5]decane-10-hydroxamic acid; 1,4-Dioxa-7-azaspiro[4.5]decane-7-carboxylic acid, 10-[(hydroxyamino)carbonyl]-, ethyl ester; Ethyl 10-(hydroxycarbamoyl)-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate; 85118-31-6; Spirocyclic hydroxamate ester.
EINECS	Contact for details

Quality Control

Our Ethyl 10-[(Hydroxyamino)Carbonyl]-1,4-Dioxa-7-Azaspiro[4.5]Decane-7-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (HPLC), related substances, and physical characterization. Our quality commitment supports cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.