Description

N(6)-(4-Azidobenzyl)Adenosine is a chemically modified nucleoside derivative, specifically engineered for advanced biochemical research and development. This compound is a critical reagent in photoaffinity labeling and click chemistry applications, enabling the study of biomolecular interactions and receptor mapping. It is primarily utilized by research scientists and pharmaceutical developers in the fields of medicinal chemistry, proteomics, and chemical biology for target identification and validation studies.

Application

• Photoaffinity Labeling: Acts as a key photoactivatable probe for covalently tagging adenosine-binding proteins and enzymes to study their structure and function.
• Click Chemistry Reagent: The azido group enables efficient, bioorthogonal conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling and pull-down assays.
• Medicinal Chemistry Research: Serves as a versatile building block for synthesizing novel adenosine receptor ligands and probes to investigate purinergic signaling pathways.
• Proteomics and Target Identification: Used to identify and characterize unknown protein targets of adenosine-based compounds in complex biological systems.
• Bioconjugation and Probe Development: Facilitates the creation of fluorescent, affinity, or therapeutic conjugates for diagnostic and therapeutic research.
• Enzyme Mechanism Studies: Employed to investigate the active sites and catalytic mechanisms of kinases, transferases, and other adenosine-utilizing enzymes.

Basic Information

Product Name	N(6)-(4-Azidobenzyl)Adenosine
CAS No.	85107-83-1
Molecular Formula	C₁₇H₁₇N₉O₄
Molecular Weight	411.38 g/mol
Synonyms	6-[(4-Azidophenyl)methyl]amino-9-β-D-ribofuranosyl-9H-purine; N6-(4-Azidobenzyl)adenosine; 4-Azidobenzyladenosine; ABz-Ado; N6-(p-Azidobenzyl)adenosine; Adenosine, N-[ (4-azidophenyl)methyl]-; N6-(4-Azidobenzyl)-adenosine
EINECS	Contact for details

Quality Control

Our N(6)-(4-Azidobenzyl)Adenosine is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our analytical methods, including HPLC and NMR, are validated to provide reliable specifications for the research community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Due to its hygroscopic and light-sensitive nature, the container should be kept in a desiccator and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.