Description

D-Aspartic Acid, 4-(1,1-Dimethylethyl) 1-Methyl Ester is a protected derivative of the non-essential amino acid D-aspartic acid, characterized by its tert-butyl and methyl ester protecting groups. This compound is a crucial high-purity chiral building block for the synthesis of complex peptides and active pharmaceutical ingredients (APIs), offering precise stereochemical control. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of therapeutic peptides, hormone analogs, and advanced biochemical research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of peptide-based drugs and hormone analogs.
• Biochemical Research: Used in studies of enzyme mechanisms, receptor-ligand interactions, and metabolic pathways involving D-amino acids.
• Peptide Synthesis: Serves as a protected D-aspartic acid residue in solid-phase and solution-phase peptide synthesis (SPPS) to prevent side reactions.
• API Development: Employed in the research and process development of new active pharmaceutical ingredients requiring D-configuration amino acids.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric reactions to construct complex molecular architectures.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	D-Aspartic Acid, 4-(1,1-Dimethylethyl) 1-Methyl Ester
CAS No.	84907-98-2
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	D-Aspartic acid β-tert-butyl ester α-methyl ester; (R)-2-(tert-Butoxycarbonylamino)succinic acid 1-methyl ester; D-Aspartic Acid 4-tert-Butyl 1-Methyl Ester; Boc-D-Asp(OMe)-OtBu; Methyl N-(tert-butoxycarbonyl)-D-aspartate; tert-Butyl D-aspartate methyl ester; (R)-1-(tert-Butyl) 4-methyl 2-((tert-butoxycarbonyl)amino)succinate
EINECS	Contact for details

Quality Control

Our D-Aspartic Acid, 4-(1,1-Dimethylethyl) 1-Methyl Ester is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.