Description

Alanine, 2-Methyl-, 1,1-Dimethylethyl Ester, Hydrochloride is a protected amino acid derivative, specifically the tert-butyl ester hydrochloride salt of 2-methylalanine. This compound serves as a crucial chiral building block in organic synthesis, offering enhanced stability and solubility for peptide coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex peptide-based drugs and therapeutic agents.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the non-proteinogenic amino acid 2-methylalanine into peptide chains.
• Protecting Group Strategy: The tert-butyl ester group provides orthogonal protection for the carboxylic acid functionality, which can be selectively cleaved under mild acidic conditions.
• Biochemical Research: Employed in studies of protein structure-function relationships, enzyme inhibitors, and as a standard in analytical method development.
• Agrochemical Synthesis: Potential intermediate in the creation of specialized amino acid-derived crop protection agents.

Basic Information

Item	Details
Product Name	Alanine, 2-Methyl-, 1,1-Dimethylethyl Ester, Hydrochloride
CAS No.	84758-81-6
Molecular Formula	C8H18ClNO2
Molecular Weight	195.69 g/mol
Synonyms	2-Methylalanine tert-Butyl Ester Hydrochloride; (R/S)-2-Aminoisobutyric Acid tert-Butyl Ester Hydrochloride; tert-Butyl 2-Amino-2-methylpropanoate Hydrochloride; 2-Aminoisobutyric Acid t-Butyl Ester HCl; AIB-OtBu·HCl; 2-Methylalanine t-Butyl Ester HCl; 2-Amino-2-methylpropionic Acid tert-Butyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our Alanine, 2-Methyl-, 1,1-Dimethylethyl Ester, Hydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (specify enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.