Description

Ifosfamide is a nitrogen mustard alkylating agent belonging to the oxazaphosphorine class of chemotherapeutic drugs. It is a critical prodrug used in the treatment of various cancers, requiring hepatic activation to exert its cytotoxic effects. This compound is essential for pharmaceutical manufacturers and research institutions developing oncology treatments. Ifosfamide CAS NO 84711-20-6 is a key active pharmaceutical ingredient (API) for producing injectable chemotherapy formulations.

Application

• Oncological Pharmaceutical Manufacturing: Primary use as an Active Pharmaceutical Ingredient (API) in the production of injectable chemotherapy drugs.
• Treatment of Solid Tumors: Used in chemotherapeutic regimens for testicular cancer, sarcomas (e.g., Ewing's sarcoma, osteosarcoma), and cervical cancer.
• Hematologic Malignancies: Component in treatment protocols for certain lymphomas.
• Pediatric Oncology: Employed in specific chemotherapy combinations for childhood cancers.
• Biomedical Research: Used as a reference standard and in preclinical studies to investigate alkylating agent mechanisms, drug resistance, and combination therapies.
• Pharmaceutical Development: Serves as a key intermediate in the research and development of new oncological therapeutics and targeted delivery systems.

Basic Information

Product Name	Ifosfamide
CAS No.	84711-20-6
Molecular Formula	C7H15Cl2N2O2P
Molecular Weight	261.09 g/mol
Synonyms	3-(2-Chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; Ifosfamidum; Isofosfamide; Ifex; Holoxan; Mitoxana; Ifomida; Naxamide; Z 4942; NSC-109724; IFO
EINECS	Contact for details

Quality Control

Our Ifosfamide is manufactured under strict quality systems to meet the exacting standards of pharmaceutical applications. Quality is assured through comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis. We provide full traceability and support regulatory submissions with Certificates of Analysis (COA) and detailed technical documentation. Production can be aligned with cGMP (current Good Manufacturing Practice) guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.