Description

Cyclobutanecarboxylic Acid, 2-(Aminocarbonyl)-, trans- (9Ci) is a specialized, high-purity organic building block featuring a cyclobutane ring substituted with both carboxylic acid and amide functional groups. This compound is valued for its unique, rigid molecular geometry, making it a critical intermediate in advanced pharmaceutical synthesis and materials science research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, where its constrained ring structure can influence biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer & Material Science: Incorporated into specialty polymers to modify thermal properties, rigidity, and biodegradability for high-performance applications.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 2-(Aminocarbonyl)-, trans- (9Ci)
CAS No.	84585-79-5
Molecular Formula	C6H9NO3
Molecular Weight	143.14 g/mol
Synonyms	trans-2-Carbamoylcyclobutanecarboxylic Acid; (1r,2r)-2-Carbamoylcyclobutanecarboxylic Acid; trans-2-Carbamoylcyclobutane-1-carboxylic Acid; 2-Carbamoylcyclobutanecarboxylic Acid (trans-); Cyclobutane-1-carboxylic acid, 2-carbamoyl-, (1R,2R)-; (1R,2R)-2-(Aminocarbonyl)cyclobutanecarboxylic Acid; trans-Cyclobutane-1,2-dicarboxamide (mono-acid)
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 2-(Aminocarbonyl)-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and comprehensive identification tests. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.