Description

(2S,3S)-2-Hydroxy-3-Methylpentanoic Acid is a high-purity chiral building block and intermediate of significant importance in asymmetric synthesis. Its defined stereochemistry makes it a valuable precursor for the production of pharmaceuticals, agrochemicals, and advanced materials where specific enantiomeric purity is critical. This compound is essential for research and development chemists and process engineers in the fine chemical, pharmaceutical, and biotechnology industries seeking to introduce complex stereocenters into target molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, antibiotic, and cardiovascular drug candidates.
• Agrochemical Synthesis: Building block for creating enantiomerically pure herbicides, fungicides, and plant growth regulators with enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands for asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Fine Chemical Production: Intermediate for flavors, fragrances, and other specialty chemicals requiring high stereochemical fidelity.
• Biochemical Research: Substrate or inhibitor in enzymatic studies and for probing metabolic pathways.
• Material Science: Monomer or modifier for synthesizing polymers with specific chiral properties.

Basic Information

Product Name	(2S,3S)-2-Hydroxy-3-Methylpentanoic Acid
CAS No.	51576-04-6
Molecular Formula	C6H12O3
Molecular Weight	132.16 g/mol
Synonyms	(2S,3S)-2-Hydroxy-3-methylpentanoic acid; (2S,3S)-3-Methyl-2-hydroxypentanoic acid; L-Threonine isomer; (2S,3S)-2-Hydroxy-3-methylvaleric acid; (2S,3S)-HMVA; (2S,3S)-3-Methyl-2-hydroxypentanoate; (2S,3S)-Hydroxy methylpentanoic acid
EINECS	Contact for details

Quality Control

Every batch of (2S,3S)-2-Hydroxy-3-Methylpentanoic Acid is produced under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, and chiral analysis to ensure high enantiomeric excess (ee) and chemical purity, meeting the stringent requirements for pharmaceutical R&D and production. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.