Description

Ethyl 3-[Bis(2-Chloroethyl)Amino]-n-(4-Fluoro-n-L-Seryl-3-Phenyl-L-Alanyl)-3-Phenyl-L-Alaninate Monohydrochloride is a complex, high-purity synthetic peptide derivative designed for advanced research and development. This compound is critical for pharmaceutical chemists and biochemists exploring novel therapeutic agents, particularly in the fields of oncology and targeted drug delivery. It serves as a key intermediate or reference standard in the synthesis of peptide-based drugs, antibody-drug conjugates (ADCs), and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex peptide therapeutics and prodrugs.
• Antibody-Drug Conjugate (ADC) Payload Research: Used in the development and optimization of cytotoxic warheads for targeted cancer therapies.
• Biochemical Research: Serves as a reference standard or substrate in enzymatic studies and proteomics research.
• Oncology Drug Discovery: Investigated for its potential as a cytotoxic agent or as part of a targeted delivery system in preclinical studies.
• Peptide Chemistry Development: Employed in methodological research for peptide coupling, protection, and modification strategies.
• Academic & Institutional Research: Used in university and government laboratories for fundamental studies in medicinal chemistry and chemical biology.

Basic Information

Product Name	Ethyl 3-[Bis(2-Chloroethyl)Amino]-n-(4-Fluoro-n-L-Seryl-3-Phenyl-L-Alanyl)-3-Phenyl-L-Alaninate Monohydrochloride
CAS No.	84434-77-5
Molecular Formula	C33H39Cl2FN4O6 • HCl
Molecular Weight	704.05 g/mol (monohydrochloride salt)
Synonyms	Ethyl 3-[bis(2-chloroethyl)amino]-N-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-fluorophenyl)propanamido]-3-phenylpropanamido]-3-hydroxypropanoyl]-3-phenylalaninate hydrochloride; L-Alanine, N-[N-[N-[N-[bis(2-chloroethyl)amino]-L-phenylalanyl]-L-phenylalanyl]-4-fluoro-L-seryl]-, ethyl ester, monohydrochloride; 4-Fluoro-L-seryl-3-phenyl-L-alanyl-3-[bis(2-chloroethyl)amino]-L-phenylalanine ethyl ester hydrochloride; Peptide derivative 84434-77-5; ADC linker-payload intermediate; Nitrogen mustard peptide conjugate.
EINECS	Contact for details

Quality Control

This high-value compound is manufactured under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for research and development. Each lot is characterized using advanced analytical techniques including HPLC, LC-MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For extended storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Titration)	97.0% - 103.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.