Description

4-Phenyl-1-(p-Tolylsulphonyl)Piperidine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique piperidine carboxylic acid core functionalized with phenyl and tosyl protecting groups. This compound matters as a critical building block in modern organic synthesis, enabling the development of novel active pharmaceutical ingredients (APIs) with complex molecular architectures. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) agents, receptor modulators, and other therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of potential drug candidates, particularly in medicinal chemistry research.
• Organic Synthesis Building Block: Used for constructing complex piperidine-based scaffolds due to its reactive carboxylic acid and protected amine functionalities.
• Research & Development (R&D): Essential for academic and industrial R&D labs exploring new chemical entities (NCEs) and structure-activity relationships (SAR).
• Process Chemistry: Employed in route scouting and optimization for the scalable production of target molecules in pilot plants and kilo labs.
• Protecting Group Chemistry: The p-tolylsulphonyl (tosyl) group serves as a valuable amine protector in complex synthetic sequences.

Basic Information

Item	Details
Product Name	4-Phenyl-1-(p-Tolylsulphonyl)Piperidine-4-Carboxylic Acid
CAS No.	84255-02-7
Molecular Formula	C19H21NO4S
Molecular Weight	359.44 g/mol
Synonyms	1-[(4-Methylphenyl)sulfonyl]-4-phenyl-4-piperidinecarboxylic acid; 4-Phenyl-1-tosyl-4-piperidinecarboxylic acid; 4-Phenyl-1-(4-toluenesulfonyl)piperidine-4-carboxylic acid; 1-Tosyl-4-phenylpiperidine-4-carboxylic acid; 4-Phenyl-1-(p-toluenesulfonyl)piperidine-4-carboxylic acid; 4-Phenyl-1-(tosyl)piperidine-4-carboxylic acid; 84255-02-7 (CAS); N-Tosyl-4-phenyl-4-piperidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Phenyl-1-(p-Tolylsulphonyl)Piperidine-4-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be stored away from direct light exposure. Keep the container tightly sealed in a dry environment to minimize moisture uptake. Store away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.