Description

3-[4-[3-(Trifluoromethyl)Phenyl]-3,6-Dihydro-2H-Pyridin-1-Yl]Propaneni Trile Hydrochloride is a high-purity, non-natural amino acid derivative and a key pharmaceutical intermediate. This compound matters for its role as a sophisticated building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily needed by pharmaceutical R&D laboratories, custom synthesis manufacturers, and agrochemical innovators seeking to develop novel compounds with enhanced biological activity.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in CNS and oncology therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, leveraging the trifluoromethyl group for improved metabolic stability and bioavailability.
• Chemical Biology & Proteomics: Serves as a specialized reagent for studying enzyme mechanisms and protein interactions due to its unique structural features.
• Material Science: Potential precursor for advanced polymers and liquid crystals where the introduction of fluorine atoms can modify material properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of client-specific molecules.
• Academic & Institutional Research: Used in university and government labs for fundamental organic chemistry and medicinal chemistry studies.

Basic Information

Product Name	3-[4-[3-(Trifluoromethyl)Phenyl]-3,6-Dihydro-2H-Pyridin-1-Yl]Propaneni Trile Hydrochloride
CAS No.	84226-24-4
Molecular Formula	C15H16F3N3·HCl
Molecular Weight	331.76 g/mol (Free base) / 368.22 g/mol (HCl salt)
Synonyms	1-(3-Cyanopropyl)-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine hydrochloride; 3-(4-(3-(Trifluoromethyl)phenyl)-3,6-dihydro-2H-pyridin-1-yl)propanenitrile hydrochloride; 4-[3-(Trifluoromethyl)phenyl]-1-(3-cyanopropyl)-1,2,3,6-tetrahydropyridine hydrochloride; 84226-24-4; 3-[4-[3-(Trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridin-1-yl]propanenitrile HCl
EINECS	Contact for details

Quality Control

Our 3-[4-[3-(Trifluoromethyl)Phenyl]-3,6-Dihydro-2H-Pyridin-1-Yl]Propaneni Trile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development from milligram to kilogram scale with consistent quality, meeting the stringent requirements for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.