Description

trans-Piperidine-2,4-Dicarboxylic Acid is a high-purity, non-proteinogenic amino acid derivative featuring a rigid piperidine backbone with two carboxylic acid functional groups. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for developing novel active pharmaceutical ingredients (APIs), peptide mimetics, and complex ligands for catalysis.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug candidates, particularly in neurology and metabolic disease research.
• Peptidomimetic Chemistry: Used to construct conformationally restricted peptide analogs to enhance metabolic stability and receptor selectivity.
• Ligand Synthesis: Serves as a precursor for chelating agents and asymmetric catalysts in metal-mediated organic transformations.
• Biochemical Research: Employed as a substrate or inhibitor analog in enzymatic studies and proteomics research.
• Material Science: Potential monomer for synthesizing novel polyamides or functional polymers with specific stereochemistry.

Basic Information

Product Name	trans-Piperidine-2,4-Dicarboxylic Acid
CAS No.	84211-44-9
Molecular Formula	C7H11NO4
Molecular Weight	173.17 g/mol
Synonyms	(2R,4S)-2,4-Piperidinedicarboxylic Acid; (2R,4S)-Piperidine-2,4-dicarboxylic Acid; trans-2,4-Piperidinedicarboxylic Acid; PDCA; (2R,4S)-PDCA; trans-Homoglutamic Acid; (2R,4S)-2-Carboxy-4-piperidinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our trans-Piperidine-2,4-Dicarboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and fine chemical synthesis. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent moisture absorption and potential degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.