Description

Mafosfamide CAS NO 84211-05-2 is a chemically stable, pre-activated derivative of the alkylating agent cyclophosphamide. This compound is of significant value in pharmaceutical research and development due to its role as a key intermediate in the synthesis of active metabolites and prodrugs. It is primarily required by researchers and manufacturers in the oncology drug development and pharmaceutical chemistry sectors for creating novel therapeutic agents and conducting metabolic studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active chemotherapeutic metabolites and related prodrug candidates.
• Oncology Research: Used in biochemical and pharmacological studies to investigate the mechanisms of alkylating agents and their cytotoxic effects.
• Metabolite Standard: Employed as a reference standard in analytical laboratories for the quantification and identification of cyclophosphamide metabolites in biological matrices.
• Prodrug Development: Acts as a model compound in the research and design of novel, targeted prodrug systems aimed at improving therapeutic efficacy and reducing side effects.
• Bioconjugation Studies: Utilized in research exploring the conjugation of cytotoxic agents to antibodies or other targeting molecules (e.g., for Antibody-Drug Conjugates - ADC research).

Basic Information

Product Name	Mafosfamide
CAS No.	84211-05-2
Molecular Formula	C₇H₁₅Cl₂N₂O₄P
Molecular Weight	293.09 g/mol
Synonyms	4-Hydroxycyclophosphamide; 4-Hydroperoxycyclophosphamide; NSC-345842; Cyclophosphamide Monohydrate; 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 4-oxide; MAF; 4-OOH-CP
EINECS	Contact for details

Quality Control

Our Mafosfamide is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.