Description

Cyclobutanecarboxylic Acid, 3-(Phenylmethoxy)-, Methyl Ester, cis- is a specialized chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. Its value lies in its unique cis-substituted cyclobutane ring system, which serves as a rigid scaffold for constructing complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where precise stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or building block for specialty polymers with unique thermal or mechanical properties.
• Academic and Contract Research: Employed in university and CRO laboratories for methodological studies and the synthesis of complex natural product analogs.
• Flavor and Fragrance Chemistry: Potential intermediate for the synthesis of high-value aroma chemicals with specific stereoisomeric profiles.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-(Phenylmethoxy)-, Methyl Ester, cis-
CAS No.	84182-49-0
Molecular Formula	C13H16O3
Molecular Weight	220.26 g/mol
Synonyms	cis-3-(Benzyloxy)cyclobutanecarboxylic acid methyl ester; Methyl cis-3-(benzyloxy)cyclobutanecarboxylate; cis-Methyl 3-(benzyloxy)cyclobutanecarboxylate; (1r,3s)-3-(Phenylmethoxy)cyclobutanecarboxylic Acid Methyl Ester; (1s,3r)-3-(Phenylmethoxy)cyclobutanecarboxylic Acid Methyl Ester; 3-Benzyloxy-cyclobutanecarboxylic acid methyl ester, cis-; Cyclobutanecarboxylic acid, 3-(benzyloxy)-, methyl ester, cis-
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 3-(Phenylmethoxy)-, Methyl Ester, cis- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high chemical and isomeric purity, meeting the exacting standards required for research and process development. Certificates of Analysis (COA) detailing identity, purity (by GC/HPLC), chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (cis-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.