Description

1-(2',4'-Difluorophenyl)-1-(4-Piperidinyl) Methanone is a high-purity, advanced pharmaceutical intermediate characterized by its distinct difluorophenyl and piperidinyl ketone structure. This compound is of significant commercial value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and other specialty drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting neurological receptors.
• Chemical Research & Development: Used as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final molecular structure of proprietary pharmaceutical compounds under development.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects and scale-up activities.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1-(2',4'-Difluorophenyl)-1-(4-Piperidinyl) Methanone
CAS No.	84162-86-7
Molecular Formula	C13H15F2NO
Molecular Weight	239.26 g/mol
Synonyms	1-(2,4-Difluorophenyl)-1-(piperidin-4-yl)methanone; 4-(2,4-Difluorobenzoyl)piperidine; 1-(2,4-Difluorophenyl)(4-piperidinyl)methanone; 4-(2,4-Difluorobenzoyl)piperidine; 84162-86-7; 1-(2,4-Difluorophenyl)-1-(4-piperidinyl)-methanone; 1-(2,4-Difluorophenyl)-1-piperidin-4-ylmethanone
EINECS	Contact for details

Quality Control

Our 1-(2',4'-Difluorophenyl)-1-(4-Piperidinyl) Methanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development and commercial projects with material that meets stringent in-house specifications, suitable for use in GMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.