Description

(3R,5R)-7-[1,2,6,7,8,8Aβ-Hexahydro-8α-[[(2S)-2-Methylbutyryl]Oxy]-2β-Methylnaphthalene-1β-Yl]-3,5-Dihydroxyheptanoic Acid is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) where precise stereochemistry is essential for biological activity. It is primarily required by pharmaceutical R&D and manufacturing sectors for the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex, high-value active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new drug candidates, particularly in metabolic and cardiovascular research.
• Process Chemistry: Serves as a critical chiral starting material or intermediate in scalable GMP manufacturing processes.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Studies: Utilized in pharmacological research to study enzyme interactions and metabolic pathways.

Basic Information

Product Name	(3R,5R)-7-[1,2,6,7,8,8Aβ-Hexahydro-8α-[[(2S)-2-Methylbutyryl]Oxy]-2β-Methylnaphthalene-1β-Yl]-3,5-Dihydroxyheptanoic Acid
CAS No.	84064-38-0
Molecular Formula	C24H36O6
Molecular Weight	420.54 g/mol
Synonyms	Atorvastatin Lactone Intermediate; (3R,5R)-Atorvastatin Lactone; (3R,5R)-7-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid lactone derivative; (3R,5R)-Atorvastatin tert-Butyl Ester Lactone Precursor; (3R-cis)-1,2,6,7,8,8a-Hexahydro-β,δ-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid; (3R,5R)-Atorvastatin Lactone Form
EINECS	Contact for details

Quality Control

Our (3R,5R)-7-[1,2,6,7,8,8Aβ-Hexahydro-8α-[[(2S)-2-Methylbutyryl]Oxy]-2β-Methylnaphthalene-1β-Yl]-3,5-Dihydroxyheptanoic Acid is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral HPLC, NMR, and mass spectrometry, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) detailing purity, impurities, and chiral excess are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (3R,5R isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.