Description

Ethyl (R)-2-(Trifluoromethylsulfonyloxy)Propionate is a high-value, chiral triflate ester building block crucial for introducing the (R)-2-propionate moiety in advanced synthetic pathways. Its primary commercial value lies in enabling asymmetric synthesis and serving as a key electrophile for cross-coupling reactions in pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), fine chemicals, and novel materials that require precise stereochemical control.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the development of chiral herbicides, fungicides, and pesticides where the specific (R)-configuration is required for biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing chiral ligands and organometallic catalysts used in asymmetric catalysis.
• Material Science Research: Employed in the creation of specialty polymers and advanced materials with tailored optical or electronic properties.
• Cross-Coupling Reactions: Acts as an effective electrophile in palladium-catalyzed reactions such as Suzuki, Negishi, and Stille couplings to form carbon-carbon bonds.
• Academic and R&D Laboratories: A valuable reagent for methodological development in organic synthesis and stereochemistry studies.

Basic Information

Product Name	Ethyl (R)-2-(Trifluoromethylsulfonyloxy)Propionate
CAS No.	84028-89-7
Molecular Formula	C7H9F3O5S
Molecular Weight	262.20 g/mol
Synonyms	(R)-Ethyl 2-((Trifluoromethyl)sulfonyloxy)propanoate; Ethyl (R)-2-(((Trifluoromethyl)sulfonyl)oxy)propanoate; (R)-Ethyl 2-(Trifluoromethanesulfonyloxy)propionate; (R)-Ethyl 2-OTf-propionate; (R)-2-(Trifluoromethanesulfonyloxy)propionic Acid Ethyl Ester; (R)-Ethyl Triflate Propionate; (R)-ETF Propionate Ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl (R)-2-(Trifluoromethylsulfonyloxy)Propionate is manufactured under strict quality management systems. We employ advanced analytical techniques, including chiral HPLC, NMR, and GC-MS, to ensure high enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, purity, assay, and impurity profiles are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.