Description

Ethyl (S)-2-(Trifluoromethylsulfonyloxy)Propionate is a high-value, chiral synthetic intermediate featuring a reactive triflate ester group. This compound matters for its critical role in facilitating stereospecific chemical transformations, particularly in the synthesis of complex, optically active molecules. Pharmaceutical and advanced agrochemical R&D laboratories need it as a key building block for creating active pharmaceutical ingredients (APIs) and other fine chemicals where precise stereochemistry is essential.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel, optically pure active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used in palladium-catalyzed cross-coupling reactions (e.g., Negishi, Suzuki-Miyaura) to introduce chiral centers with high enantiomeric purity.
• Agrochemical Research: Serves as a precursor in the development of enantiomerically defined herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Employed in the synthesis of sophisticated chiral ligands and organocatalysts for asymmetric catalysis.
• Material Science: Potential monomer or modifier for creating specialty polymers with unique fluorinated properties.
• Academic & Process Chemistry: A valuable reagent for methodological development and scale-up studies in organic synthesis.

Basic Information

Product Name	Ethyl (S)-2-(Trifluoromethylsulfonyloxy)Propionate
CAS No.	84028-88-6
Molecular Formula	C7H9F3O5S
Molecular Weight	262.20 g/mol
Synonyms	(S)-Ethyl 2-((Trifluoromethyl)sulfonyloxy)propanoate; (S)-Ethyl 2-(Trifluoromethanesulfonyloxy)propionate; Ethyl (S)-2-(((Trifluoromethyl)sulfonyl)oxy)propanoate; (S)-Ethyl 2-(Triflyloxy)propionate; (S)-2-(Trifluoromethanesulfonyloxy)propionic Acid Ethyl Ester; Propanoic acid, 2-[[(trifluoromethyl)sulfonyl]oxy]-, ethyl ester, (2S)-; (S)-ETFPO; (S)-Ethyl Triflate Propionate
EINECS	Contact for details

Quality Control

Our Ethyl (S)-2-(Trifluoromethylsulfonyloxy)Propionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and purity assessment, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place, preferably at 2-8°C for long-term stability. The compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.