Description

Methyl n-Formyl-3-Oxo-n-(1-Phenylethyl)-Alaninate is a specialized chiral α-amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a crucial building block for the preparation of complex peptides and peptidomimetics, offering a protected and activated ester form for efficient coupling reactions. It is primarily utilized by research institutions and pharmaceutical development companies engaged in the synthesis of novel bioactive molecules, including protease inhibitors and other therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease-targeted therapies.
• Peptidomimetic Synthesis: Used as a constrained amino acid analog for constructing non-natural peptide backbones with enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore novel chemical space and optimize drug candidate properties.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to introduce chiral centers.
• Bioconjugation Chemistry: Potential use in the site-specific modification of peptides and proteins due to its reactive ester and formyl groups.

Basic Information

Product Name	Methyl n-Formyl-3-Oxo-n-(1-Phenylethyl)-Alaninate
CAS No.	83898-12-8
Molecular Formula	C14H17NO4
Molecular Weight	263.29 g/mol
Synonyms	Methyl (2R)-2-[(1S)-1-phenylethyl]-3-oxo-2-(formylamino)propanoate; Methyl N-Formyl-3-oxo-N-[(1S)-1-phenylethyl]-D-alaninate; N-Formyl-3-oxo-N-(1-phenylethyl)alanine methyl ester; (2R)-2-[(1S)-1-Phenylethyl]-3-oxo-2-(formylamino)propanoic acid methyl ester; N-Formyl-N-(1-phenylethyl)-3-oxoalanine methyl ester; Alaninate derivative, Methyl n-formyl-3-oxo-n-(1-phenylethyl)-
EINECS	Contact for details

Quality Control

Our Methyl n-Formyl-3-Oxo-n-(1-Phenylethyl)-Alaninate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. We provide comprehensive analytical data, including chiral purity verification by HPLC. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with every batch to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product should be kept under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.