Description

Piperaquine is a bisquinoline antimalarial compound of significant pharmaceutical importance. Its primary value lies in its potent and long-lasting activity against Plasmodium falciparum, including chloroquine-resistant strains, making it a cornerstone in modern combination therapies. This active pharmaceutical ingredient (API) is essential for manufacturers in the global pharmaceutical industry developing and producing antimalarial medications, particularly for use in Artemisinin-based Combination Therapies (ACTs).

Application

• Antimalarial Pharmaceutical Formulations: Primary use as the key active ingredient in fixed-dose combination therapies, most notably with dihydroartemisinin.
• Research & Development: Serves as a critical reference standard and starting material for pharmacological studies, efficacy testing, and new drug development targeting malaria parasites.
• Global Health Programs: Bulk manufacturing for procurement by international health organizations (e.g., WHO, UNICEF) for distribution in malaria-endemic regions.
• Veterinary Antiprotozoal Applications: Potential use in veterinary medicine for treating analogous parasitic infections in animals.
• Chemical Synthesis Intermediate: Used in the synthesis of novel quinoline derivatives and analogs for broader antimicrobial research.

Basic Information

Item	Detail
Product Name	Piperaquine
CAS No.	83764-65-2
Molecular Formula	C29H32Cl2N6
Molecular Weight	535.51 g/mol
Synonyms	Piperaquine Phosphate (common salt form); 1,3-Bis[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propane; 1,3-Bis(4-(7-chloro-4-quinolyl)-1-piperazinyl)propane; GP 46624; 13228W; RP 13228W; Antimalarial Agent GP-46624; UNII-4RZ82L2GY5
EINECS	Contact for details

Quality Control

Our Piperaquine is manufactured and tested under strict quality management systems to meet the exacting standards required for pharmaceutical active ingredients. Quality assurance includes comprehensive analytical testing for identity, purity, and impurity profiles, aligning with ICH guidelines. A Certificate of Analysis (COA) is provided with each batch, detailing results for assay, related substances, residual solvents, and other critical parameters. We support compliance with major pharmacopoeial standards, including USP and EP, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 1.5%
Water Content (KF)	NMT 2.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.