Description

Methyl 4,4,4-Trifluoroacetoacetate is a versatile fluorinated β-ketoester building block, essential for introducing the trifluoromethyl group into complex molecular architectures. Its high reactivity makes it a critical intermediate for synthesizing advanced pharmaceuticals, agrochemicals, and specialty materials. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and fine chemical industries seeking to enhance the metabolic stability and bioavailability of their target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethylpyrazole and other fluorinated heterocycles.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the CF₃ group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for β-diketone ligands used in coordination chemistry and catalysis.
• Material Science: Employed in the research and development of fluorinated polymers and advanced organic electronic materials.
• Chemical Research: A fundamental reagent in organic synthesis for Claisen condensations, Michael additions, and heterocycle formation.

Basic Information

Product Name	Methyl 4,4,4-Trifluoroacetoacetate
CAS No.	83643-84-9
Molecular Formula	C₅H₅F₃O₃
Molecular Weight	170.09 g/mol
Synonyms	Methyl 4,4,4-trifluoro-3-oxobutanoate; 4,4,4-Trifluoroacetoacetic Acid Methyl Ester; Methyl Trifluoroacetoacetate; 3-Oxo-4,4,4-trifluorobutanoic Acid Methyl Ester; Methyl 3-Oxo-4,4,4-trifluorobutanoate; MTFAA; TFAA Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 4,4,4-Trifluoroacetoacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.