Description

3,5-Difluorophenylisocyanate is a versatile and highly reactive aromatic isocyanate building block, essential for introducing the 3,5-difluorophenyl moiety into advanced molecular structures. Its primary value lies in enabling the synthesis of compounds with enhanced biological activity and specific physicochemical properties through urea and carbamate formation. This intermediate is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluorophenyl group contributes to efficacy and environmental stability.
• Polymer & Material Science: Serves as a monomer or cross-linking agent in the manufacture of specialty polyurethanes, coatings, and adhesives with tailored performance characteristics.
• Ligand & Catalyst Development: Employed in organic and organometallic chemistry to create novel ligands for catalytic systems and molecular recognition.
• Chemical Research & Development: A fundamental reagent for medicinal chemistry and process chemistry in lead optimization and scale-up activities.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated components for electronic display and lighting technologies.

Basic Information

Product Name	3,5-Difluorophenylisocyanate
CAS No.	83594-83-6
Molecular Formula	C7H3F2NO
Molecular Weight	155.10 g/mol
Synonyms	3,5-Difluorophenyl isocyanate; Isocyanic Acid, 3,5-Difluorophenyl Ester; 1-Isocyanato-3,5-difluorobenzene; 3,5-Difluorobenzene Isocyanate; m,m-Difluorophenyl Isocyanate; 3,5-Difluorophenyl Isocyanat; 3,5-Difluorophenylisocyanat; 83594-83-6
EINECS	Contact for details

Quality Control

Our 3,5-Difluorophenylisocyanate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive quality assurance, supported by Certificates of Analysis (COA) for each lot, detailing purity, identity, and impurity profiles. Our quality protocols are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, open flames, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.