Description

(S)-2-Pyridylthio Cysteamine Hydrochloride is a high-purity chiral building block and biochemical reagent, essential for advanced organic synthesis and bioconjugation. Its core value lies in its role as a versatile intermediate for introducing thiol-reactive pyridyl disulfide groups, enabling the creation of stable, cleavable linkages in complex molecules. This compound is critically needed by research institutions and pharmaceutical companies engaged in the development of antibody-drug conjugates (ADCs), peptide modification, and targeted drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a key intermediate for constructing cleavable disulfide linkers that connect cytotoxic payloads to monoclonal antibodies.
• Peptide and Protein Modification: Used for site-specific introduction of thiol-reactive handles onto peptides, proteins, and other biomolecules for labeling or functionalization.
• Bioconjugation and Cross-linking: Enables the formation of reversible disulfide bonds between molecules, a crucial technique in proteomics and diagnostic assay development.
• Pharmaceutical Intermediate: Acts as a chiral synthon in the multi-step synthesis of novel therapeutic agents, particularly in oncology and targeted therapies.
• Surface Functionalization: Utilized to modify nanoparticles, biosensors, and chromatographic media with pyridyl disulfide groups for controlled immobilization of biomolecules.
• Research & Development: A vital tool in academic and industrial R&D for exploring new drug delivery mechanisms and biochemical pathways.

Basic Information

Product Name	(S)-2-Pyridylthio Cysteamine Hydrochloride
CAS No.	83578-21-6
Molecular Formula	C7H11ClN2S2
Molecular Weight	222.76 g/mol
Synonyms	(S)-2-(2-Pyridinyldithio)ethanamine Hydrochloride; (S)-2-Pyridyldithioethylamine Hydrochloride; (S)-Pyridyl-2-dithioethylamine HCl; (S)-PDA Hydrochloride; (S)-Cysteamine, 2-pyridylthio-, hydrochloride; L-Cysteamine, S-(2-pyridinyl)-, hydrochloride; (2S)-2-Aminoethanethiol S-(2-pyridinyl) ester hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2-Pyridylthio Cysteamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.