Description

(+/-)-cis-4-Hydroxynipecotic Acid Methyl Ester CAS NO 83563-72-8 is a high-purity, versatile nipecotic acid derivative that serves as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in its functionalized piperidine ring structure, which is essential for constructing complex molecules with specific stereochemistry. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets, as well as by fine chemical manufacturers producing custom intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel pharmaceutical compounds, especially those targeting neurological pathways.
• GABA Receptor Research: Used as a precursor or analog in the synthesis of ligands for GABA (γ-aminobutyric acid) receptor studies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in catalytic asymmetric synthesis due to its defined cis-stereochemistry.
• Fine Chemical Production: Used in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic & Industrial R&D: A standard reagent in organic chemistry laboratories for method development and the exploration of new synthetic routes.

Basic Information

Product Name	(+/-)-cis-4-Hydroxynipecotic Acid Methyl Ester
CAS No.	83563-72-8
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	Methyl 4-hydroxypiperidine-3-carboxylate (racemic cis); cis-4-Hydroxynipecotic acid methyl ester; Methyl cis-4-hydroxynipecotate; 3-Carbomethoxy-4-hydroxypiperidine; 4-Hydroxy-3-piperidinecarboxylic acid methyl ester; (±)-cis-Methyl 4-hydroxynipecotate; rac-Methyl cis-4-hydroxynipecotate
EINECS	Contact for details

Quality Control

Our (+/-)-cis-4-Hydroxynipecotic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm isomeric composition, ensuring compliance with research and development grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (cis-isomer)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.