Description

6'-Chloro-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic indole scaffold. This compound is valued for its role as a critical building block in the synthesis of novel bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Chemical Biology Probes: Utilized to create tool compounds for investigating enzyme function and cellular signaling mechanisms.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis and scale-up projects under cGMP conditions.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	6'-Chloro-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One
CAS No.	83419-49-2
Molecular Formula	C10H8ClNO
Molecular Weight	193.63 g/mol
Synonyms	6'-Chloro-1'H-spiro[cyclopropane-1,3'-indol]-2'(1'H)-one; 6'-Chloro-1'H-spiro[cyclopropane-1,3'-indole]-2'-one; 6-Chlorospiro[cyclopropane-1,3'-indolin]-2'-one; 2H-Spiro[cyclopropane-1,3'-indol]-2'-one, 6'-chloro-1'H-; 6'-Chloro-1'H-spiro[cyclopropane-1,3'-indolin]-2-one; 83419-49-2; Spiro[cyclopropane-1,3'-indole]-2'-one, 6'-chloro-1'H-
EINECS	Contact for details

Quality Control

Our 6'-Chloro-1'H-Spiro[Cyclopropane-1,3'-Indole]-2'-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for advanced pharmaceutical intermediates to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.