Description

(S)-Isobutyl-2-Chloropropanoate is a chiral ester building block of significant interest in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and specialty agrochemicals. This high-purity compound is essential for research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, enantiomerically pure intermediates for process development and scale-up.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in routes requiring the (S)-2-chloropropanoic acid moiety.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and insecticides where the specific stereochemistry enhances biological activity and reduces environmental impact.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Fine Chemical Manufacturing: Employed in the multi-step synthesis of complex fragrance compounds, flavors, and other high-value specialty chemicals.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry, enabling research into new stereoselective transformations.

Basic Information

Product Name	(S)-Isobutyl-2-Chloropropanoate
CAS No.	83261-15-8
Molecular Formula	C7H13ClO2
Molecular Weight	164.63 g/mol
Synonyms	(S)-2-Chloropropanoic Acid Isobutyl Ester; (S)-Isobutyl 2-Chloropropionate; (S)-2-Chloro-1-methyl-ethyl isobutyrate; L-Isobutyl 2-chloropropanoate; (S)-(-)-Isobutyl 2-chloropropanoate; Propanoic acid, 2-chloro-, (2S)-, 2-methylpropyl ester; Isobutyl (S)-2-chloropropionate
EINECS	Contact for details

Quality Control

Our (S)-Isobutyl-2-Chloropropanoate is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, enantiomeric excess (e.e.), and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical development and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% e.e.
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.