Description

Glucose-1-Methylenephosphonate is a specialized organophosphorus compound where a methylenephosphonate group is linked to the C1 position of a glucose molecule. This unique structure makes it a valuable intermediate and building block in medicinal chemistry and biochemical research, particularly for developing enzyme inhibitors and phosphate mimetics. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and life science sectors for drug discovery and the synthesis of bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nucleotide analogs and other bioactive compounds targeting metabolic pathways.
• Enzyme Inhibition Studies: Acts as a phosphate or phosphonate mimic in the development of inhibitors for glycosidases and kinases.
• Biochemical Research: Used as a substrate analog to study carbohydrate metabolism and phosphorylation processes.
• Agrochemical Development: Potential intermediate in creating novel plant growth regulators or herbicides with specific modes of action.
• Chelating Agent Precursor: Serves as a starting material for synthesizing complexing agents with affinity for calcium and other metal ions.
• Material Science: Investigated for incorporation into functional polymers or surface coatings due to its polar and potentially chelating properties.

Basic Information

Product Name	Glucose-1-Methylenephosphonate
CAS No.	82977-27-3
Molecular Formula	C7H15O9P
Molecular Weight	274.16 g/mol
Synonyms	1-Deoxy-1-(phosphonomethyl)-D-glucitol; D-Glucitol, 1-deoxy-1-(phosphonomethyl)-; 1-(Phosphonomethyl)-1-deoxy-D-glucitol; Glucose 1-Methylenephosphonic Acid; G1MP; (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexylphosphonic Acid
EINECS	Contact for details

Quality Control

Our Glucose-1-Methylenephosphonate is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Ensure the storage area is well-ventilated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.