Description

Diamminechloro(Guanosine-N(7))Platinum(II) is a specialized organoplatinum coordination compound, representing a key intermediate in the development of novel platinum-based anticancer agents. Its primary value lies in its role as a model compound for studying the binding interactions of platinum drugs with nucleobases, particularly guanosine, which is critical for understanding DNA adduct formation and mechanism of action. This product is essential for pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on oncology drug discovery and the synthesis of advanced platinum complexes.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and synthetic intermediate in the discovery and development of next-generation platinum-based chemotherapeutic agents.
• Mechanistic Biochemical Studies: Used to investigate the specific binding modes and kinetics of platinum compounds with DNA, particularly at the N7 position of guanine residues.
• Academic Research: A valuable tool for universities and research institutes studying bioinorganic chemistry, metallodrug design, and the structure-activity relationships of metal-based anticancer drugs.
• Fine Chemical Synthesis: Employed as a building block for the preparation of more complex, targeted platinum coordination compounds with potential enhanced efficacy or reduced side-effect profiles.
• Analytical Reference Material: Used as a high-purity standard in analytical methods (e.g., HPLC, LC-MS) for quantifying platinum drug metabolites or related impurities.

Basic Information

Product Name	Diamminechloro(Guanosine-N(7))Platinum(II)
CAS No.	82758-00-7
Molecular Formula	C10H17ClN8O5Pt
Molecular Weight	575.84 g/mol
Synonyms	Diamminechloroguanosineplatinum(II); Chloro(diammine)(guanosine-N7)platinum; Guanosinediamminechloroplatinum(II); Platinum, chloro(diammine)(guanosine-kN7)-; (SP-4-2)-Chloro(diammine)(guanosine-kN7)platinum; Guanine nucleoside platinum complex; Platinum-guanosine adduct; Diammine(guanosine)chloroplatinum(II)
EINECS	Contact for details

Quality Control

Our Diamminechloro(Guanosine-N(7))Platinum(II) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from key tests including assay (by HPLC or titration), identification (IR, NMR), and related substance analysis. We support research and development with material that meets exacting standards for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (TLC)	Single major spot
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.