Description

Methyl (4S,5S)-Dihydro-5-Methyl-2-Phenyl-4-Oxazolecarboxylate is a high-purity, chiral oxazolidinone derivative that serves as a critical building block in asymmetric synthesis. Its defined stereochemistry makes it an invaluable reagent for the preparation of enantiomerically pure pharmaceutical intermediates and fine chemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in antiviral and central nervous system (CNS) drug candidates.
• Asymmetric Auxiliary: Used as a chiral auxiliary or ligand in asymmetric catalysis to induce stereoselectivity in carbon-carbon and carbon-heteroatom bond-forming reactions.
• Agrochemical Synthesis: Employed in the research and development of chiral pesticides and herbicides where specific stereochemistry is required for bioactivity.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic & Industrial R&D: A valuable tool for chemists in method development and exploring new synthetic routes in organic and medicinal chemistry.
• Material Science: Potential use in the synthesis of chiral polymers or liquid crystals with specific optical properties.

Basic Information

Product Name	Methyl (4S,5S)-Dihydro-5-Methyl-2-Phenyl-4-Oxazolecarboxylate
CAS No.	82659-84-5
Molecular Formula	C12H13NO3
Molecular Weight	219.24 g/mol
Synonyms	(4S,5S)-4-(Methoxycarbonyl)-5-methyl-2-phenyl-4,5-dihydrooxazole; Methyl (4S,5S)-5-methyl-2-phenyl-4,5-dihydrooxazole-4-carboxylate; (4S,5S)-5-Methyl-2-phenyl-4-oxazolinecarboxylic acid methyl ester; (4S-cis)-4-(Methoxycarbonyl)-5-methyl-2-phenyl-2-oxazoline; Chiral Evans Auxiliary derivative; (S,S)-Phenyloxazolidinone carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl (4S,5S)-Dihydro-5-Methyl-2-Phenyl-4-Oxazolecarboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and optical rotation measurement. Certificates of Analysis (COA) detailing purity, enantiomeric excess (ee), and full analytical data are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.