Description

(+)-tert-Butyl (S)-3-Hydroxybutyrate is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a protected form of (S)-3-hydroxybutyric acid, providing a versatile handle for stereoselective reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of active pharmaceutical ingredients (APIs), chiral catalysts, and complex natural products.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of β-lactam antibiotics, statins, and other stereochemically complex drug molecules.
• Asymmetric Synthesis: Used in the preparation of chiral ligands, auxiliaries, and catalysts for enantioselective transformations.
• Natural Product Synthesis: Serves as a building block for the total synthesis of macrolides, polyketides, and other natural compounds with defined stereocenters.
• Biochemical Research: Employed in studies related to ketone body metabolism and as a precursor for labeled compounds in metabolic tracing.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Product Name	(+)-tert-Butyl (S)-3-Hydroxybutyrate
CAS No.	82578-45-8
Molecular Formula	C8H16O3
Molecular Weight	160.21 g/mol
Synonyms	(S)-3-Hydroxybutyric acid tert-butyl ester; (S)-(-)-3-Hydroxybutyric acid tert-butyl ester; tert-Butyl (S)-3-hydroxybutanoate; (S)-3-Hydroxybutanoic acid tert-butyl ester; (S)-(-)-3-Hydroxybutyric acid t-butyl ester; (S)-3-HB-tBu ester; (S)-HBA-tBu
EINECS	Contact for details

Quality Control

Our (+)-tert-Butyl (S)-3-Hydroxybutyrate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity (typically ≥98%), enantiomeric excess (typically ≥99%), and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.