Description

1-Triisopropylsilyl-1-Propyne is a specialized organosilicon reagent featuring a terminal alkyne group protected by a bulky triisopropylsilyl (TIPS) moiety. This compound matters as a critical building block in advanced organic synthesis, offering excellent stability and selectivity for complex molecule construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as click chemistry, Sonogashira couplings, and the synthesis of conjugated polymers.

Application

• Pharmaceutical Intermediate Synthesis: Used as a protected acetylene synthon in the construction of complex drug candidates and active pharmaceutical ingredients (APIs).
• Click Chemistry & Bioconjugation: Serves as a key reagent in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for labeling biomolecules and developing diagnostic probes.
• Materials Science & Polymer Chemistry: Employed in the synthesis of conjugated polymers, molecular wires, and advanced organic electronic materials due to its stable alkyne functionality.
• Agrochemical Research: Acts as a versatile building block for creating novel compounds with potential herbicidal or insecticidal activity.
• Cross-Coupling Reactions: A reliable substrate in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand and Catalyst Development: Used to prepare sophisticated ligands and organometallic catalysts for asymmetric synthesis.

Basic Information

Product Name	1-Triisopropylsilyl-1-Propyne
CAS No.	82192-57-2
Molecular Formula	C15H30Si
Molecular Weight	238.49 g/mol
Synonyms	Triisopropyl(prop-1-yn-1-yl)silane; TIPS-Propyne; (Prop-1-yn-1-yl)triisopropylsilane; 1-Propyn-1-yltriisopropylsilane; 1-Propynyltriisopropylsilane; Triisopropylsilylacetylene; TIPS-acetylene; 1-(Triisopropylsilyl)propyne
EINECS	Contact for details

Quality Control

Our 1-Triisopropylsilyl-1-Propyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced chemical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.