Description

Lumefantrine CAS NO 82186-77-4 is a synthetic aryl amino alcohol antimalarial agent, belonging to the fluorene derivative class. It is a critical component in the global fight against malaria, particularly for its synergistic efficacy when combined with artemisinin derivatives. This active pharmaceutical ingredient (API) is essential for manufacturers of antimalarial combination therapies targeting both uncomplicated and multi-drug resistant strains of *Plasmodium falciparum*. Its role in first-line treatment regimens underscores its importance in public health and pharmaceutical supply chains worldwide.

Application

• Primary Antimalarial Therapy: As the key component in Artemisinin-based Combination Therapies (ACTs), most notably in combination with Artemether (Coartem®/Riamet®), for the treatment of acute, uncomplicated malaria caused by *Plasmodium falciparum*.
• Pharmaceutical Formulation: Serves as the core Active Pharmaceutical Ingredient (API) in the manufacture of tablets, dispersible tablets, and other oral dosage forms for global health programs and commercial markets.
• Drug Development & Research: Used in preclinical and clinical research for developing new antimalarial formulations and studying drug resistance mechanisms.
• Global Health Procurement: Supplied to international organizations (e.g., WHO, UNICEF), government tenders, and NGOs for large-scale malaria treatment and prevention initiatives in endemic regions.
• Generic Pharmaceutical Manufacturing: A vital raw material for generic drug manufacturers producing WHO-prequalified and FDA-approved antimalarial medicines.

Basic Information

Product Name	Lumefantrine
CAS No.	82186-77-4
Molecular Formula	C30H32Cl3NO
Molecular Weight	528.94 g/mol
Synonyms	Benflumetol; 2-Dibutylamino-1-[2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol; 1-[(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl]-2-(dibutylamino)ethanol; CGP 56695; Halfan (discontinued brand); Component of Coartem (Artemether/Lumefantrine); Component of Riamet.
EINECS	Contact for details

Quality Control

Our Lumefantrine is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards including USP, EP, and IP. Each batch undergoes rigorous analytical testing for identity, purity, potency, and specified impurities to ensure it meets the stringent requirements for pharmaceutical API production. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment. We support audits and can supply documentation for regulatory submissions (e.g., DMFs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.